Inclusion Criteria
Participants are eligible to be included in the trial if ALL the following apply:
- Age 21 years or older
- First-detected AFib (defined as AFib diagnosed in the previous 120 days)
- Electrocardiographic documentation of atrial fibrillation
- Estimated life expectancy of at least 1 year
- Patient or legal authorized representative capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) of the trial protocol
Exclusion Criteria
Participants are excluded from the trial if ANY of the following criteria apply:
- Patients with prior or planned treatment with rhythm control, either catheter ablation or chronic (>7 days) antiarrhythmic drug therapy
- Planned cardiothoracic surgery
- New York Heart Association class III or IV heart failure or a hospitalization for heart failure in the last 4 weeks
- Reduced ejection fraction (LVEF ≤40%)
- Permanent atrial fibrillation
- Ineligible for oral anticoagulation, unless CHA2DS2-VASc is less than 3, in women, or 2, in men.
- Bradycardia with a resting heart rate < 50 bpm
- PR interval >280 msec or 2nd degree or 3rd degree atrioventricular block without a permanent pacemaker/cardiac implanted electronic device
- Corrected QT interval ³500 msec
- Pregnancy or breast feeding
- Severe hepatic impairment in the opinion of the investigator