What are the patient eligibility inclusion and exclusion criteria?

Inclusion Criteria
Participants are eligible to be included in the trial if ALL the following apply:

  • Age 60 years or older
  • First-detected AFib (defined as AFib diagnosed in the previous 60 days)
  • Electrocardiographic documentation of atrial fibrillation
  • Estimated life expectancy of at least 1 year
  • Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) of the trial protocol

Exclusion Criteria
Participants are excluded from the trial if ANY of the following criteria apply:

  • Prior or planned treatment with rhythm control, either catheter ablation or antiarrhythmic drug therapy
  • Prior hospitalization for AFib
  • Planned cardiothoracic surgery
  • New York Heart Association class III or IV heart failure or a hospitalization for heart failure in the last 4 weeks
  • Reduced ejection fraction (LVEF ≤40%)
  • Permanent atrial fibrillation
  • Ineligible for oral anticoagulation, unless CHA2DS2-VASc is less than 3, in women, or 2, in men.
  • Bradycardia with a resting heart rate < 50 bpm
  • PR interval >280 msec or 2nd degree or 3rd degree atrioventricular block without a permanent pacemaker/cardiac implanted electronic device
  • Corrected QT interval ³500 msec
  • Pregnancy
  • Severe hepatic impairment