Doctor examining patient

The CHANGE AFib trial closed and is no longer enrolling trial sites or subjects.

Doctor examining patient

A Common Problem

Atrial Fibrillation (AFib) is an irregular heartbeat, and it is the most common arrhythmia seen in clinical practice. Anyone can develop AFib. It can lead to heart complications and increases the risk of having a stroke by five times.

Millions of Americans have AFib, and that number continues to rise. It is estimated that by 2030 AFib will affect 12.1 million people in the United States, which is more than double the number in 2010.

First Pragmatic Trial

Establishing treatment options for newly diagnosed patients is an integral part of a care plan to help patients live longer, healthier lives. This is the first pragmatic trial to focus on identifying treatment best practices for first-detected AFib. This trial is a collaboration between the American Heart Association®, the world’s leading nonprofit organization focused on heart and brain health, and the Duke Clinical Research Institute (DCRI), the world’s largest academic clinical research organization, with support from Sanofi US.

* This is an estimate of the number of people in the United States who currently have AFib.